Dinauer Lab

Mary Dinauer, MD, PhD, studies the superoxide-generating leukocyte NADPH oxidase and the role of oxidant production by neutrophils and macrophages in microbial killing, the inflammatory response, and autoimmunity. Inactivating mutations in the NADPH oxidase result in chronic granulomatous disease (CGD), a primary immunodeficiency associated with recurrent bacterial and fungal infections as well as a variety of chronic inflammatory disorders, including inflammatory bowel disease and discoid lupus. Moreover, hypomorphic NADPH oxidase gene variants are now linked to inflammatory bowel disease and autoimmunity. These clinical manifestations reflect the dual importance of the NADPH oxidase both for microbial killing and for negatively regulating cellular processes that limit inflammation by redox mechanisms.

Principal investigator

Mary C. Dinauer, MD, PhD

Fred M. Saigh Distinguished Chair in Pediatric Research, Washington University School of Medicine
Professor, Pathology & Immunology
Scientific Director, Children’s Discovery Institute, Washington University School of Medicine

• Phone: 314-454-6018
• Email: mdinauer@wustl.edu

Recent publications

• Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in Mice
  November 15, 2022
  Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in MiceIdol, R. A., Bhattacharya, S., Huang, G., Song, Z., Huttenlocher, A., Keller, N. P. & Dinauer, M. C., Nov 15 2022, In: Journal of Immunology. 209, 10, p. 1960-1972 13 p.Research output: Contribution to journal › Article › peer-review
• Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice
  May 12, 2022
  Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in miceBhattacharya, S., Idol, R. A., Yang, W., Rojas Márquez, J. D., Li, Y., Huang, G., Beatty, W. L., Atkinson, J. J., Brumell, J. H., Bagaitkar, J., Magee, J. A. & Dinauer, M. C., May 12 2022, In: Blood. 139, 19, p. 2855-2870 16 p.Research output: Contribution to journal › Article › peer-review
• Derivation of extra-embryonic and intra-embryonic macrophage lineages from human pluripotent stem cells
  April 1, 2022
  Derivation of extra-embryonic and intra-embryonic macrophage lineages from human pluripotent stem cellsBredemeyer, A. L., Amrute, J. M., Koenig, A. L., Idol, R. A., He, L., Luff, S. A., Dege, C., Leid, J. M., Schilling, J. D., Hinson, J. T., Dinauer, M. C., Sturgeon, C. M. & Lavine, K. J., Apr 2022, In: Development (Cambridge). 149, 8, dev200016.Research output: Contribution to journal › Article › peer-review
• Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation
  November 9, 2021
  Neutrophil DREAM promotes neutrophil recruitment in vascular inflammationLi, J., Kumari, T., Barazia, A., Jha, V., Jeong, S. Y., Olson, A., Kim, M., Lee, B. K., Manickam, V., Song, Z., Clemens, R., Razani, B., Kim, J., Dinauer, M. C. & Cho, J., Nov 9 2021, In: Journal of Experimental Medicine. 219, 1, e20211083.Research output: Contribution to journal › Article › peer-review
• X-linked Chronic Granulomatous Disease Presenting with Mediastinal Lipoblastoma and Adjacent Pneumonia
  November 1, 2021
  X-linked Chronic Granulomatous Disease Presenting with Mediastinal Lipoblastoma and Adjacent PneumoniaBigley, T. M., Song, Z., Orscheln, R. C., Wilson, D. B., Shakhsheer, B. A., He, M., Sweet, S. C., Dinauer, M. C. & Kitcharoensakkul, M., Nov 2021, In: Journal of Clinical Immunology. 41, 8, p. 1969-1971 3 p.Research output: Contribution to journal › Letter › peer-review

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