Shenoy Lab

Shalini Shenoy, MD, MBBS

My academic focus is on the development of safer less toxic methods of hematopoietic stem cell transplantation in children. Toward this, I am investigating reduced intensity transplantation for children with hemoglobinopathy (sickle cell disease and thalassemia) using the best available related or alternate donors.  

Based on a preliminary multi-center trial that was previously completed, a national trial of unrelated donor marrow transplantation for severe sickle cell disease is ongoing under the Bone Marrow Transplant Clinical Trials Network (BMT CTN) and is called the SCURT Trial (BMT CTN 0601). 

Another trial for thalassemia has just been completed under the Thalassemia Clinical research Network (TCRN) and Pediatric Blood and Marrow transplant Consortium (PBMTC) – called the URTH trial. We are now exploring reduced intensity transplantation for non-malignant disorders including hemoglobinopathy using minimally mismatched marrow or cord blood donors in a separate study (01-0923).

Principal investigator

Shalini  Shenoy, MD, MBBS

Shalini Shenoy, MD, MBBS

Professor of Pediatrics, Hematology & Oncology
Director, Stem Cell Transplant & Cellular Therapy Program

Recent publications

  • Overlap chronic GVHD is associated with adverse survival outcomes compared to classic chronic GVHDGorfinkel, L., Raghunandan, S., Watkins, B., Hebert, K., Neuberg, D. S., Bratrude, B., Betz, K., Yu, A., Choi, S. W., Davis, J., Duncan, C., Giller, R., Grimley, M., Harris, A. C., Jacobsohn, D., Lalefar, N., Farhadfar, N., Pulsipher, M. A., Shenoy, S. & Petrovic, A. & 7 others, Schultz, K. R., Yanik, G. A., Blazar, B. R., Horan, J. T., Langston, A., Kean, L. S. & Qayed, M., May 2024, In: Bone Marrow Transplantation. 59, 5, p. 680-687 8 p.Research output: Contribution to journal › Article › […]
  • Long-term outcomes after unrelated donor transplantation for severe sickle cell disease on the BMT CTN 0601 trialEapen, M., Kou, J., Andreansky, M., Bhatia, M., Brochstein, J., Chaudhury, S., Haight, A. E., Haines, H., Jacobsohn, D., Jaroscak, J., Kasow, K. A., Krishnamurti, L., Levine, J. E., Leung, K., Margolis, D., Yu, L. C., Horowitz, M. M., Kamani, N., Walters, M. C. & Shenoy, S., Apr 2024, In: American journal of hematology. 99, 4, p. 785-788 4 p.Research output: Contribution to journal › Letter › peer-review
  • Neurocognitive outcome in children with sickle cell disease after myeloimmunoablative conditioning and haploidentical hematopoietic stem cell transplantation: a non-randomized clinical trialBraniecki, S., Vichinsky, E., Walters, M. C., Shenoy, S., Shi, Q., Moore, T. B., Talano, J. A., Parsons, S. K., Flower, A., Panarella, A., Fabricatore, S., Morris, E., Mahanti, H., Milner, J., McKinstry, R. C., Duncan, C. N., van de Ven, C. & Cairo, M. S., 2024, In: Frontiers in Neurology. 15, 1263373.Research output: Contribution to journal › Article › peer-review
  • Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantationPfeiffer, T., Lockowitz, C. R., Shenoy, S., Mavers, M., Hayashi, R., Bednarski, J. & Green, A., 2024, (Accepted/In press) In: Bone Marrow Transplantation.Research output: Contribution to journal › Letter › peer-review
  • Hyperthyroidism following transplantation and SARS-CoV-2 exposureElnaggar, M. & Shenoy, S., Dec 2023, In: Pediatric Blood and Cancer. 70, 12, e30713.Research output: Contribution to journal › Letter › peer-review