Shenoy Lab

Shalini Shenoy, MD, MBBS

My academic focus is on the development of safer less toxic methods of hematopoietic stem cell transplantation in children. Toward this, I am investigating reduced intensity transplantation for children with hemoglobinopathy (sickle cell disease and thalassemia) using the best available related or alternate donors.  

Based on a preliminary multi-center trial that was previously completed, a national trial of unrelated donor marrow transplantation for severe sickle cell disease is ongoing under the Bone Marrow Transplant Clinical Trials Network (BMT CTN) and is called the SCURT Trial (BMT CTN 0601). 

Another trial for thalassemia has just been completed under the Thalassemia Clinical research Network (TCRN) and Pediatric Blood and Marrow transplant Consortium (PBMTC) – called the URTH trial. We are now exploring reduced intensity transplantation for non-malignant disorders including hemoglobinopathy using minimally mismatched marrow or cord blood donors in a separate study (01-0923).

Principal investigator

Shalini Shenoy, MD, MBBS

Professor of Pediatrics, Hematology and Oncology
Director, Stem Cell Transplant & Cellular Therapy Program

Recent publications

  • Normalization of cerebral hemodynamics after hematopoietic stem cell transplant in children with sickle cell diseaseHulbert, M. L., Fields, M. E., Guilliams, K. P., Bijlani, P., Shenoy, S., Fellah, S., Towerman, A. S., Binkley, M. M., McKinstry, R. C., Shimony, J. S., Chen, Y., Eldeniz, C., Ragan, D. K., Vo, K., An, H., Lee, J. M. & Ford, A. L., Jan 26 2023, In: Blood. 141, 4, p. 335-344 10 p.Research output: Contribution to journal › Article › peer-review
  • Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantationLabrosse, R., Boufaied, I., Bourdin, B., Gona, S., Randolph, H. E., Logan, B. R., Bourbonnais, S., Berthe, C., Chan, W., Buckley, R. H., Parrott, R. E., Cuvelier, G. D. E., Kapoor, N., Chandra, S., Dávila Saldaña, B. J., Eissa, H., Goldman, F. D., Heimall, J., O'Reilly, R., Chaudhury, S., & 13 othersKolb, E. A., Shenoy, S., Griffith, L. M., Pulsipher, M., Kohn, D. B., Notarangelo, L. D., Pai, S. Y., Cowan, M. J., Dvorak, C. C., Haddad, É., Puck, J. M., Barreiro, L. B. & Decaluwe, H., […]
  • Long-Term Organ Function After HCT for SCD: A Report From the Sickle Cell Transplant Advocacy and Research AllianceStenger, E., Xiang, Y., Wetzel, M., Gillespie, S., Chellapandian, D., Shah, R., Arnold, S. D., Bhatia, M., Chaudhury, S., Eckrich, M. J., Kanter, J., Kasow, K. A., Krajewski, J., Nickel, R. S., Ngwube, A. I., Olson, T. S., Rangarajan, H. G., Wobma, H., Guilcher, G. M. T., Horan, J. T., & 3 othersKrishnamurti, L., Shenoy, S. & Abraham, A., Jan 2023, In: Transplantation and Cellular Therapy. 29, 1, p. 47.e1-47.e10Research output: Contribution to journal › Article › peer-review
  • Organ function indications and potential improvements following curative therapy for sickle cell diseaseHulbert, M. L., King, A. A. & Shenoy, S., Dec 9 2022, In: Hematology (United States). 2022, 1, p. 277-282 6 p.Research output: Contribution to journal › Article › peer-review
  • Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell diseaseChu, Y., Talano, J. A., Baxter-Lowe, L. A., Verbsky, J. W., Morris, E., Mahanti, H., Ayello, J., Keever-Taylor, C., Johnson, B., Weinberg, R. S., Shi, Q., Moore, T. B., Fabricatore, S., Grossman, B., van de Ven, C., Shenoy, S. & Cairo, M. S., Dec 9 2022, In: Frontiers in immunology. 13, 1055497.Research output: Contribution to journal › Article › peer-review