Shenoy Lab

My academic focus is on the development of safer less toxic methods of hematopoietic stem cell transplantation in children. Toward this, I am investigating reduced intensity transplantation for children with hemoglobinopathy (sickle cell disease and thalassemia) using the best available related or alternate donors.  

Based on a preliminary multi-center trial that was previously completed, a national trial of unrelated donor marrow transplantation for severe sickle cell disease is ongoing under the Bone Marrow Transplant Clinical Trials Network (BMT CTN) and is called the SCURT Trial (BMT CTN 0601). 

Another trial for thalassemia has just been completed under the Thalassemia Clinical research Network (TCRN) and Pediatric Blood and Marrow transplant Consortium (PBMTC) – called the URTH trial. We are now exploring reduced intensity transplantation for non-malignant disorders including hemoglobinopathy using minimally mismatched marrow or cord blood donors in a separate study (01-0923).

Principal investigator

Shalini Shenoy, MD, MBBS

Professor of Pediatrics, Hematology and Oncology
Director, Stem Cell Transplant & Cellular Therapy Program

• Phone: 314-454-6018
• Email: shenoy@wustl.edu

Recent publications

• Hematopoietic Cell Transplantation for Congenital Dyserythropoietic Anemia: A Report from the Pediatric Transplant and Cellular Therapy Consortium
  June 1, 2022
  Hematopoietic Cell Transplantation for Congenital Dyserythropoietic Anemia: A Report from the Pediatric Transplant and Cellular Therapy ConsortiumRangarajan, H. G., Stanek, J. R., Abdel-Azim, H., Modi, A., Haight, A., McKinney, C. M., McKeone, D. J., Buchbinder, D. K., Katsanis, E., Abusin, G. A., Ahmed, I., Law, J., Silva, J. G., Mallhi, K. K., Burroughs, L. M., Shah, N., Shaw, P. J., Greiner, R., Shenoy, S., Pulsipher, M. A., & 1 othersAbu-Arja, R., Jun 2022, In: Transplantation and Cellular Therapy. 28, 6, p. 329.e1-329.e9Research output: Contribution to journal › Article › peer-review
• Benefits of newborn screening and hematopoietic cell transplant in infantile Krabbe disease
  May 10, 2022
  Benefits of newborn screening and hematopoietic cell transplant in infantile Krabbe diseasePage, K. M., Ream, M. A., Rangarajan, H. G., Galindo, R., Mian, A. Y., Ho, M. L., Provenzale, J., Gustafson, K. E., Rubin, J., Shenoy, S. & Kurtzberg, J., May 10 2022, In: Blood Advances. 6, 9, p. 2947-2956 10 p.Research output: Contribution to journal › Article › peer-review
• Case Report: “Primary Immunodeficiency”—Severe Autoimmune Enteropathy in a Pediatric Heart Transplant Recipient Treated With Abatacept and Alemtuzumab
  April 5, 2022
  Case Report: “Primary Immunodeficiency”—Severe Autoimmune Enteropathy in a Pediatric Heart Transplant Recipient Treated With Abatacept and AlemtuzumabKalaidina, E., Utterson, E. C., Mokshagundam, D., He, M., Shenoy, S. & Cooper, M. A., Apr 5 2022, In: Frontiers in immunology. 13, 863218.Research output: Contribution to journal › Article › peer-review
• Significant improvement of child physical and emotional functioning after familial haploidentical stem cell transplant
  April 1, 2022
  Significant improvement of child physical and emotional functioning after familial haploidentical stem cell transplantParsons, S. K., Rodday, A. M., Weidner, R. A., Morris, E., Braniecki, S., Shenoy, S., Talano, J. A., Moore, T. B., Panarella, A., Flower, A., Milner, J., Fabricatore, S., Mahanti, H., van de Ven, C., Shi, Q. & Cairo, M. S., Apr 2022, In: Bone Marrow Transplantation. 57, 4, p. 586-592 7 p.Research output: Contribution to journal › Article › peer-review
• Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders
  March 1, 2022
  Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disordersMarsh, R. A., Hebert, K., Kim, S., Dvorak, C. C., Aquino, V. M., Baker, K. S., Chellapandian, D., Dávila Saldaña, B., Duncan, C. N., Eckrich, M. J., Georges, G. E., Olson, T. S., Pulsipher, M. A., Shenoy, S., Stenger, E., Lugt, M. V., Yu, L. C., Gennery, A. R. & Eapen, M., Mar 2022, In: Journal of Allergy and Clinical Immunology. 149, 3, p. 1097-1104.e2Research output: Contribution to journal › Article › peer-review